Synonyms

Granular cell myoblastoma

Category

Soft tissue

Behaviour

Benign

Gender

Female

Tissue of Origin

Neural

Epidemiology

• Benign nerve sheath tumour derivative
• Peak incidence in 3rd-5th decades
• Female predilection particularly in breast

Clinical Features

• Firm subcutaneous nodule
• Often solitary
• Usually painless
• Breast presentation can mimic malignancy

Location

• Skin and subcutaneous (most common)
• Breast
• Respiratory tract
• GI tract

Imaging

• MRI: well-defined lesion
• Ultrasound: hypoechoic nodule

Pathology

• Nested cells with abundant granular cytoplasm
• S100+, neuron-specific enolase+
• No atypia

Genetics

Sporadic

Treatment

• Observation or surgical excision
• Complete excision reduces recurrence

Prognosis

Excellent - Benign, rare transformation to malignancy

Key Points

• Benign Neural tumour
• Rarely undergo Malignant transformation

Workup - Blood Tests

No specific blood tests

Workup - Local Imaging

MRI or ultrasound for characterisation

Workup - Biopsy

Biopsy if diagnosis uncertain

Workup - Staging

No staging required

Workup - Other

Excision for definitive diagnosis and treatment

Follow-up Summary

Year 1: Post-operative visit within first 6 weeks, then supported discharge