Synonyms

High-grade liposarcoma variant

Category

Soft tissue

Behaviour

Malignant

Grade

High

Gender

Both equally

Tissue of Origin

Adipose

Epidemiology

• Rare High-grade liposarcoma variant
• Peak incidence in middle-aged adults
• Lower extremity predominance

Clinical Features

• Large, rapidly growing mass
• Often presents with advanced disease

Location

• Lower extremity
• Retroperitoneum

Imaging

• MRI: heterogeneous High-grade appearance
• Minimal lipid content - mostly solid

Pathology

• Pleomorphic lipoblasts and undifferentiated sarcoma
• High mitotic rate, extensive necrosis
• Liposarcoma grade 3 (Highest)

Genetics

• Complex karyotype
• FUS, MDM2 may be present

Treatment

• Wide surgical excision
• Chemotherapy indicated

Prognosis

Poor - High-grade malignancy with metastatic potential

Key Points

• Highest-grade liposarcoma variant
• Aggressive behaviour - multimodal therapy required

Workup - Blood Tests

FBC, U&E, LFTs, LDH - baseline

Workup - Local Imaging

• MRI primary site - local staging
• CT chest/abdomen/pelvis - metastatic staging

Workup - Biopsy

Core needle biopsy - confirm diagnosis

Workup - Staging

CT chest/abdomen/pelvis - metastases

Follow-up Summary

• Year 1: Post-operative at 6 weeks; 3–4 monthly clinical examination and CXR
• Year 2: 3–4 monthly clinical examination and CXR
• Years 3–4: 6-monthly clinical examination and CXR
• Years 5–10: Annual clinical examination and CXR
• Discharge at 10 years after surgery